Package: TRD
Type: Package
Title: Transmission Ratio Distortion
Version: 1.0
Date: 2015-01-21
Author: Lam Opal Huang
Maintainer: Lam Opal Huang <opal.huang@mail.mcgill.ca>
Depends: Rlab (>= 2.14.0)
Description: Transmission Ratio Distortion (TRD) is a genetic phenomenon where two alleles from either parent are not transmitted to the offspring at the Mendelian 1:1 ratio. Occurrence of TRD in general population can lead to false inflation or attenuation of association signals in case populations. Therefore, it is necessary to adjust for TRD in model fitting of case populations. This package uses models such as loglinear model (Weinberg 1998), augmented loglinear model (Huang 2014), and tests such as TDT (Spielman 1993), augmented TDT (Labbe 2013), on simulated or real datasets. This package has a simulation function which generates a population that is under the influence of TRD, and samples a sub-population, which can serve as the dataset to fit a loglinear model or to perform a TDT. Real dataset with the same data structure as described in the help file of the function 'll' can also be used in the loglinear model and the TDT functions. No real dataset is included in this package.   
License: GPL (>= 2)
Packaged: 2015-01-21 18:53:44 UTC; Opal - AL
NeedsCompilation: no
Repository: CRAN
Date/Publication: 2015-01-22 00:48:35
Built: R 3.1.2; ; 2015-01-22 14:58:52 UTC; unix
