Toolkit to identify synthetic lethality and cell line resistance relationships based on bimodality in gene expression data.

Documentation for package ‘BiSEp’ version 1.0

BiSEp-package	BiSEp: Bimodality in gene expression to dissect tumours and reveal synthetic lethal drug targets and biomarkers
BEEM	BEEM: Bimodal Expression Exclusive with Mutation
BEEM_EXPRS	A Log2 Gene Expression matrix
BEEM_MUT	A matrix containing discreet mutation calls
BEEP	BEEP: Bimodal Expression Exclusive with Pharmacology
BEEP_input_data	Gene by sample input data matrix.
BEEP_sens_data	Matrix containing sample names and discreet pharmacology calls.
BIGEE	BIGEE: Bimodal Gene Expression Exclusivity.
BIGEE_example_input	A data matrix containing log2 gene expression data
BISEP	BISEP: Bimodality in Gene Expression data.
BiSEp	BiSEp: Bimodality in gene expression to dissect tumours and reveal synthetic lethal drug targets and biomarkers
FURE	FURE: Functional redundancy between synthetic lethal gene pairs
FURE_example_input	Output matrix from the SLinG tool