| MultEq-package {MultEq} | R Documentation |
The package provides tests and confidence intervals for comparing two treatments when there is more than one primary response variable (endpoint) given. The step-up procedure of Quan et al. (2001) is both applied for differences and extended to ratios of means of normally distributed data with equal group variances. A related single-step procedure is also available.
| Package: | MultEq |
| Type: | Package |
| Version: | 2.0 |
| Date: | 2008-01-30 |
| License: | GPL |
Mario Hasler
Maintainer: Mario Hasler <hasler@biostat.uni-hannover.de>
Hothorn, L.A. and Hasler, M. (in process): Proof of hazard and proof of safety in toxicological studies using simultaneous confidence intervals for differences and ratios to control; Quan et al. (2001): Assessmant of equivalence on multiple endpoints, Statistics in Medicine 20, 3159-3173
data(clinic)
comp <- multeq.diff(data=clinic,grp="fact",method="step.up",margin.up=rep(0.6,5),
margin.lo=-rep(0.6,5))
summary(comp)