PBG {nlme} | R Documentation

## Effect of Phenylbiguanide on Blood Pressure

### Description

The `PBG` data frame has 60 rows and 5 columns.

### Format

This data frame contains the following columns:

deltaBP
  a numeric vector
dose
  a numeric vector
Run
  an ordered factor with levels `T5` < `T4` < `T3` < `T2` < `T1` < `P5` < `P3` < `P2` < `P4` < `P1`
Treatment
  a factor with levels `MDL 72222` `Placebo`
Rabbit
  an ordered factor with levels `5` < `3` < `2` < `4` < `1`

### Details

Data on an experiment to examine the effect of a antagonist MDL 72222 on the change in blood pressure experienced with increasing dosage of phenylbiguanide are described in Ludbrook (1994) and analyzed in Venables and Ripley (1999, section 8.8). Each of five rabbits was exposed to increasing doses of phenylbiguanide after having either a placebo or the HD5-antagonist MDL 72222 administered.

### Source

Pinheiro, J. C. and Bates, D. M. (2000), Mixed-Effects Models in S and S-PLUS, Springer, New York. (Appendix A.21)

Venables, W. N. and Ripley, B. D. (1999) Modern Applied Statistics with S-PLUS (3rd ed), Springer, New York.

Ludbrook, J. (1994), Repeated measurements and multiple comparisons in cardiovascular research, Cardiovascular Research, 28, 303-311.

### Examples

    data(PBG)

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