Package: TEQR
Version: 1.0-0
Date: 2010-10-16
Title: Target Equavelence Range Design
Author: M. Suzette Blanchard <sblanchard@coh.org>
Depends:
Maintainer: M. Suzette Blanchard <sblanchard@coh.org>
Description: The target equivalence range (TEQR) design is a
        frequentist implementation of the modified toxicity probability
        interval (mTPI) design and a competitor to the standard 3+3
        design (3+3).  The 3+3 is the work horse design in Phase I. It
        is good at determining if a safe dose exits, but provides poor
        accuracy and precision in estimating the level of toxicity at
        the maximum tolerated dose (MTD).  The TEQR is better than the
        3+3 when compared on: 1) the number of times the dose at or
        nearest the target toxicity level was selected as the MTD, 2)
        the number of subjects assigned to doses levels, at or nearest
        the MTD, and 3) the overall trial DLT rate. TEQR more
        accurately and more precisely estimates the rate of toxicity at
        the MTD because a larger number of subjects are studied at the
        MTD dose. The TEQR on average uses fewer subjects and provide
        reasonably comparable results to the continual reassessment
        method (CRM) in the number of times the dose at or nearest the
        target toxicity level was selected as the MTD and the number of
        subjects assigned doses, at, or nearest the target and in
        overall DLT rate.
License: GPL-2
Packaged: 2010-11-09 17:26:43 UTC; root
Repository: CRAN
Date/Publication: 2010-11-10 11:16:57
Built: R 2.13.2; ; 2011-09-30 18:07:20 UTC; windows
