AUC                    package:PK                    R Documentation

_A_r_e_a _U_n_d_e_r _t_h_e _C_o_n_c_e_n_t_r_a_t_i_o_n _T_i_m_e _C_u_r_v_e

_D_e_s_c_r_i_p_t_i_o_n:

     Estimation of area under the concentration time curve (AUC) and
     area under the first moment curve (AUMC).

_U_s_a_g_e:

     AUC(conc, time, exact=NA, numintp=2, numtail=3, prev=0)  

_A_r_g_u_m_e_n_t_s:

    conc: levels of concentrations. 

    time: time points of concentration assessment. 

   exact: time point for linear interpolation/extrapolation. 

 numintp: number of last data points used for linear
          interpolation/extrapolation. 

 numtail: number of last data points used for tail area correction. 

    prev: pre-dosing value. 

_D_e_t_a_i_l_s:

     Estimation of the observed area under the concentration time curve
     (AUC 0-tlast) and observed area under the first moment curve (AUMC
     0-tlast) using the linear trapezoidal method. 

     Estimation of the linearly interpolated area under the
     concentration time curve (AUC 0-exact) and linearly interpolated
     area under the moment curve (AUMC 0-exact). The time point for
     linear interpolation/extrapolation must be after the last but one
     time point of concentration assessments. 

     Estimation of the total area under the concentration curve (AUC
     0-infinity) and total area under the first moment curve (AUMC
     0-infinity) by using a tail area correction similar as suggested
     by Perrier and Gibaldi (Appendix D, 1982). 

     If the pre-dosing value indicating that the intrinsic level is
     greater than 0, the pre-dosing value is subtracted from all
     concentration levels before calculation of AUC and AUMC.

_V_a_l_u_e:

     Data frame including AUC and AUMC estimates

_N_o_t_e:

     Records including missing values and values below zero are
     omitted.

_A_u_t_h_o_r(_s):

     Martin J. Wolfsegger and Thomas Jaki

_R_e_f_e_r_e_n_c_e_s:

     Gibaldi M. and Perrier D. (1982). _Pharmacokinetics. 2nd Edition_.
     Marcel Dekker, New York and Basel.  

      Cawello W. (1998). _Parameter zur modellunabhngigen
     Pharmakokinetik_. Shaker Verlag, Aachen. 


_E_x_a_m_p_l_e_s:

     ## example from Cawello W. (1998, page 71-74)
     time <- c(0, 0.25, 0.5, 0.75, 1, 1.5, 2, 2.5, 3, 4, 5, 6)
     conc <- c(0, 5.67, 20.6, 28.7, 22.5, 17.4, 17.7, 13.4, 11.0, 8.23, 5.14, 2.84) 
     AUC(conc=conc, time=time, exact=7, numtail=4)

