bos                   package:msm                   R Documentation

_B_r_o_n_c_h_i_o_l_i_t_i_s _o_b_l_i_t_e_r_a_n_s _s_y_n_d_r_o_m_e _a_f_t_e_r _l_u_n_g _t_r_a_n_s_p_l_a_n_t_s

_D_e_s_c_r_i_p_t_i_o_n:

     A dataset containing histories of bronchiolitis obliterans
     syndrome (BOS) from lung transplant recipients. BOS is a chronic
     decline in lung function, often observed after lung
     transplantation. The condition is classified into four stages of
     severity: none, mild, moderate and severe.

_U_s_a_g_e:

     data(bos)

_F_o_r_m_a_t:

     A data frame containing 638 rows, grouped by patient, including
     histories of 204 patients. The first observation for each patient
     is defined to be stage 1, no BOS, at six months after transplant. 
     Subsequent observations denote the entry times into stages 2, 3,
     4, representing mild, moderate and severe BOS respectively, and
     stage 5, representing death.   

       'ptnum'  (numeric)  Patient identification number
        'time'  (numeric)  Months after transplant
       'state'  (numeric)  BOS state entered at this time

_D_e_t_a_i_l_s:

     The entry time of each patient into each stage of BOS was
     estimated by clinicians, based on their history of lung function
     measurements and acute rejection and infection episodes.  BOS is
     only assumed to occur beyond six months after transplant.   In the
     first six months the function of each patient's new lung
     stabilises.  Subsequently BOS is diagnosed by comparing the lung
     function against the "baseline" value.

_S_o_u_r_c_e:

     Papworth Hospital, U.K.

_R_e_f_e_r_e_n_c_e_s:

     Heng. D. et al. (1998).  Bronchiolitis Obliterans Syndrome:
     Incidence, Natural History, Prognosis, and Risk Factors.  Journal
     of Heart and Lung Transplantation 17(12)1255-1263.

