Lanza                 package:HSAUR                 R Documentation

_P_r_e_v_e_n_t_i_o_n _o_f _G_a_s_t_o_i_n_t_e_s_t_i_n_a_l _D_a_m_a_g_e_s

_D_e_s_c_r_i_p_t_i_o_n:

     Data from four randomised clinical trials on the prevention of 
     gastointestinal damages by Misoprostol reported by Lanza et al.
     (1987, 1988a,b, 1989).

_U_s_a_g_e:

     data("Lanza")

_F_o_r_m_a_t:

     A data frame with 198 observations on the following 3 variables.

     '_s_t_u_d_y' a factor with levels 'I', 'II', 'III', and 'IV' describing
          the study number.

     '_t_r_e_a_t_m_e_n_t' a factor with levels 'Misoprostol' 'Placebo'

     '_c_l_a_s_s_i_f_i_c_a_t_i_o_n' an ordered factor with levels '1' < '2' < '3' <
          '4' < '5' describing an ordered response variable.

_D_e_t_a_i_l_s:

     The response variable is defined by the number of haemorrhages or
     erosions.

_S_o_u_r_c_e:

     F. L. Lanza (1987), A double-blind study of prophylactic effect of
     misoprostol on lesions of gastric and duodenal mucosa induced by
     oral administration of tolmetin  in healthy subjects. _British
     Journal of Clinical Practice_, May suppl, 91-101.

     F. L. Lanza, R. L. Aspinall, E. A. Swabb, R. E. Davis, M. F. Rack,
     A. Rubin (1988a), Double-blind, placebo-controlled endoscopic
     comparison of the mucosal protective effects of misoprostol versus
     cimetidine on tolmetin-induced mucosal injury to the stomach and
     duodenum.  _Gastroenterology_, *95*(2), 289-294.

     F. L. Lanza, K. Peace, L. Gustitus, M. F. Rack, B. Dickson
     (1988b), A blinded endoscopic comparative study of misoprostol
     versus sucralfate and placebo in the prevention of aspirin-induced
     gastric and duodenal ulceration. _American Journal of
     Gastroenterology_, *83*(2), 143-146.

     F. L. Lanza, D. Fakouhi, A. Rubin, R. E. Davis, M. F. Rack, C.
     Nissen, S. Geis (1989), A double-blind placebo-controlled
     comparison of the efficacy and safety of 50, 100, and 200
     micrograms of misoprostol QID in the prevention of
     ibuprofen-induced gastric and duodenal mucosal lesions and
     symptoms. _American Journal of  Gastroenterology_, *84*(6),
     633-636.

_E_x_a_m_p_l_e_s:

       data("Lanza", package = "HSAUR")
       layout(matrix(1:4, nrow = 2))
       pl <- tapply(1:nrow(Lanza), Lanza$study, function(indx)
           mosaicplot(table(Lanza[indx,"treatment"], 
                            Lanza[indx,"classification"]),
                      main = "", shade = TRUE))

