betablocker {flexmix} | R Documentation

## Clinical trial of beta-blockers

### Description

22-centre clinical trial of beta-blockers for reducing mortality after myocardial infarction.

### Usage

    data("betablocker")

### Format

A data frame with 44 observations on the following 4 variables.

Deaths
  Number of deaths.
Total
  Total number of patients.
Center
  Number of clinical centre.
Treatment
  A factor with levels `Control` and `Treated`.

### Source

G. McLachlan and D. Peel (2000): Finite Mixture Models. John Wiley and Sons Inc. http://www.maths.uq.edu.au/~gjm/DATA/mmdata.html

### References

M. Aitkin (1999): Meta-analysis by random effect modelling in generalized linear models. Statistics in medicine 18, pages 2343-2351.

S. Yusuf, R. Peto, J. Lewis, R. Collins and P. Sleight (1985): Beta blockade during and after myocardial infarction: an overview of the randomized trials. Progress in Cardiovascular Diseases 27, pages 335-371.

### Examples

    data("betablocker")
    betaMix <- stepFlexmix(cbind(Deaths, Total-Deaths) ~ 1 | Center,
                           data=betablocker, k=3, nrep=5,
                           model=FLXMRglmfix(family="binomial",
                             fixed=~Treatment))

[Package flexmix version 2.2-4 Index]