toenail                package:glmmAK                R Documentation

_T_o_e_n_a_i_l _i_n_f_e_c_t_i_o_n

_D_e_s_c_r_i_p_t_i_o_n:

     This data set considers information from a longitudinal clinical
     trial in dermatology which was set up to compare the efficacy of
     two oral treatments for toenail infection (De Backer at al.,
     1998).  One of the end points of the study was the degree of
     onycholysis which expresses the degree of separation of the nail
     plate from the nail-bed (0, absent; 1, mild; 2, moderate; 3,
     severe) and was evaluated at seven visits (approximately on weeks
     0, 4, 8, 12, 24, 36 and 48). In total, 1 908 measurements on 294
     patients are available. In this dataset, only a dichotomized
     onycholysis (0, absent or mild; 1, moderate or severe) is given
     (variable 'infect').

     *IMPORTANT NOTICE:* The data have kindly been made available by
     Novartis, Belgium. The source of the data must be acknowledged in
     any publication which uses them (see Lesaffre and Spiessens, 2001
     for more details).

_U_s_a_g_e:

     data(toenail)

_F_o_r_m_a_t:

     A data frame with 1908 observations on the following 5 variables.

     '_i_d_n_r' identification number of the patient

     '_i_n_f_e_c_t' binary response

     '_t_r_t' treatment group

     '_t_i_m_e' time of measurement (in months)

     '_v_i_s_i_t' visit number    

_S_o_u_r_c_e:

     Lesaffre, E. and Spiessens, B. (2001). On the effect of the number
     of quadrature points in a logistic random-effects model: An
     example. _Applied Statistics_, *50*, 325-335.

_R_e_f_e_r_e_n_c_e_s:

     De Backer, M., De Vroey, C., Lesaffre, E., Scheys, I., and De
     Keyser, P. (1998). Twelve weeks of continuous onychomycosis caused
     by dermatophytes: A double blind comparative trial of terbafine
     250 mg/day versus itraconazole 200 mg/day. _Journal of the
     American Academy of Dermatology_, *38*, S57-S63.

_E_x_a_m_p_l_e_s:

     data(toenail)
     ## maybe str(toenail); plot(toenail) ...

