apoai                 package:lemma                 R Documentation

_T_h_e _A_P_O-_A_I _d_a_t_a _s_e_t (_C_a_l_l_o_w _e_t _a_l., _2_0_0_0)

_D_e_s_c_r_i_p_t_i_o_n:

     The ApoA1 experiment (Callow et al., 2000) used gene targeting in
     embryonic stem cells to produce mice lacking apolipprotein A-1, a
     gene known to play a critical role in high density lipoprotein
     (HDL) cholesterol levels. Originally, 5,600 expressed sequence
     tags (EST) were selected. For this data set, we used the data and
     normalization method provided with the LIMMA R package (Smyth,
     2005), which consists of 5,548 ESTs, from 8 control (wild type
     "black six") mice and 8 "knockout" (lacking ApoA1) mice. Common
     reference RNA was obtained by pooling RNA from the control mice,
     and was used to perform expression profiling for all 16 mice. The
     response of interest  is the log2 fluorescence ratio (with respect
     to the common reference).

_U_s_a_g_e:

     apoai

_F_o_r_m_a_t:

     A data frame containing 5,548 rows and 18 columns.  The first
     column contains the gene IDs, the second column contains the gene
     names.  Columns 3-11 contain the reponses for the 8 mice in the
     control group, and columns 12-18 contain the reponses for the 8
     mice in the treatment group.

_R_e_f_e_r_e_n_c_e_s:

     Callow, M. J., Dudoit, S., Gong, E. L., Speed, T. P. and Rubin, E.
     M. (2000). Microarray expression profiling identifies genes with
     altered expression in HDL-deficient mice. Genome Res, 10 2022-9.

