Mutagenicity             package:mratios             R Documentation

_M_u_t_a_g_e_n_i_c_i_t_y _a_s_s_a_y

_D_e_s_c_r_i_p_t_i_o_n:

     Mutagenicity assay for 4 doses of a compound (hydroquinone)
     against a negative (vehicle) control and a positive (active)
     control (cyclophosphamide).  Hydroquinone was applied in doses of
     30, 50, 70, 100 mg/kg, positive control was applied with 25mg/kg.
     Counts of micronuclei in polychromatic erythrocytes after 24h are
     taken as a measure for the potency to induce chromosome damage.
     Data of male mice are presented (Hauschke et al., 2005).

_U_s_a_g_e:

     data(Mutagenicity)

_F_o_r_m_a_t:

     A data frame with 31 observations on the following 2 variables.

     _T_r_e_a_t_m_e_n_t a factor with levels Cyclo25, Hydro100, Hydro30,
          Hydro50, Hydro75, Vehicle

     _M_N a numeric vector, giving the counts of micronuclei after 24h

_S_o_u_r_c_e:

     _Adler, ID, and Kliesch, U (1990)._ Comparison of single and
     multiple treatment regiments in the mouse bone marrow micronucleus
     assay for hydroquinone and cyclophosphamide. _Mutation Research
     234, 115-123._

_R_e_f_e_r_e_n_c_e_s:

     _Hauschke, D, Slacik-Erben, R, Hansen, S, Kaufmann,R (2005)._
     Biostatistical Assessment of mutagenicity studies by including the
     positive control. _Biometrical Journal 47, 82-87._

_E_x_a_m_p_l_e_s:

     data(Mutagenicity)

     str(Mutagenicity)

     boxplot(MN~Treatment, data=Mutagenicity)

