# Randomization for Clinical Trials

## Documentation for package ‘randomizeR’ version 1.4

- DESCRIPTION file.
- User guides, package vignettes and other documentation.

## Help Pages

A B C D E G H I K L M N O P R S T U misc

randomizeR-package | Randomization for Clinical Trials

## -- A --

a | Function returning the adjusting parameter a slot of an S4 object
abcdPar | Representing Accelerated Biased Coin Design
abcdRand | Sampling algorithm for abcd
assess | Assessing randomization sequences
assess-method | Assessing randomization sequences

## -- B --

bbcdPar | Representing Bayesian Biased Coin Design
bbcdRand | Sampling algorithm for bbcd
blocks | Function returning the block slot of an S4 object
bsdPar | Representing Big Stick Design
bsdRand | Sampling algorithm for BSD

## -- C --

calcProb | Theoretical probability for randomization sequences
calculateProbabilities | Theoretical probability for randomization sequences
chenPar | Representing Chen's Design
chenRand | Representing Chen's Design
chronBias | Representing chronological bias
coin | Function returning the coin slot of an S4 object
combineBias | Combined additive bias criterion
compare | Comparison of randomization procedures
compare-method | Comparison of randomization procedures
corGuess | Representing the expected number of correct guesses
createParam | Representing any randomization procedure
createSeq | Query to create a randomization sequence of a particular randomization procedure
crPar | Representing Complete Randomization

## -- D --

derFunc | Representing Derringer-Suich desirability functions
derFunc-class | Parameters generic
desirability | Desirability functions within the scope of clinical trials
doublyF_opt | Distribution function of the non central F-distribution
doublyF_value | Rejection probability for one sequence in the presence of selection bias
doublyF_values | Rejection probability in case of selection bias in multi-arm trials
doublyT | Approximation of the distribution function of the doubly noncentral t-distribution
doublyTValues | Calculation of the biased type-one-error (resp. power) of Student's t-test

## -- E --

ebcPar | Representing Efron's Biased Coin Design
evaluate | Evaluation of several randomization procedures with respect to certain desirability functions applied to specified issues.
evaluate-method | Evaluation of several randomization procedures with respect to certain desirability functions applied to specified issues.

## -- G --

gbcdPar | Representing Generalized Biased Coin Design
gbcdRand | Sampling algorithm for gbcd
generateAllSequences | Complete set of randomization sequences
generateRandomSequences | Generate random sequences
genNcps | Calculation of the NCPs of each randomization sequence for the doubly noncentral t-distribution
genSeq | Generate random sequences
genSeq-method | Generate random sequences
getAllSeq | Complete set of randomization sequences
getAllSeq-method | Complete set of randomization sequences
getbiasCS1 | Biasing Policy for a Group of Favoured Treatments
getbiasCS2 | Biasing Policy for Avoiding the Placebo Treatment
getCorGuesses | Matrix of the guesses of the investigator
getDesFunc | Type of Desirability function
getDesFunc-method | Type of Desirability function
getDesign | Design of a randomization procedure
getDesign-method | Design of a randomization procedure
getDesScores | Applying desirability functions on issues of individual randomization sequences
getDesScores-method | Applying desirability functions on issues of individual randomization sequences
getExpectation | Get expectations of a randomization list
getExpectation-method | Get expectations of a randomization list
getProb | Theoretical probability for randomization sequences
getProb-method | Theoretical probability for randomization sequences
getProbabilities | Theoretical probability for randomization sequences
getRandList | Accessor function for the randomization list
getRandomizationList | Accessor function for the randomization list

## -- H --

hadaPar | Representing Hadamard Randomization
hasAllGroups | Check function for occurance of all treatment groups in the sequence
hatMatrix | Calculate hat matrix

## -- I --

imbal | Representing the allocation imbalance
issue | Assessment criteria for clinical trials
issues | Assessment criteria for clinical trials

## -- K --

K | Function returning the total sample size slot of an S4 object

## -- L --

lambda1 | Calculate first non centrality parameter of the doubly non central F-distribution
lambda2 | Calculate second non centrality parameter of the doubly non central F-distribution

## -- M --

makeBiasedExpectation | Calculate Expectation vector
makeDesignMatrix | Design Matrix
method | Function returning the allocation ratio slot of an S4 object
mpPar | Representing Maximal Procedure
mti | Function returning the MTI slot of an S4 object
mu | Access the expectation value slot of a normEndp S4 object

## -- N --

N | Function returning the sample size slot of an S4 object
normEndp | Representation of normally distributed endpoints

## -- O --

overview | Overview over the parameters used in the 'randomizeR' package

## -- P --

pbrPar | Representing Permuted Block Randomization
plot | Generic plotting of comparison objects
plot-method | Generic plotting of comparison objects
plotDes | desScore plotting
plotEv | Evaluation plotting
plotSeq | Sequence plotting
probUnDes | Computing the probability of having desirabilty scores of zero
probUnDes-method | Computing the probability of having desirabilty scores of zero

## -- R --

randBlocks | Function returning the block slot of an S4 object
randomizeR | Randomization for Clinical Trials
randPar | Settings for randomization procedures
randPar-class | Randomization paramters
randSeq-class | An S4 Class for the representation of randomization sequences
rarPar | Representing Random Allocation Rule
ratio | Function returning the allocation ratio slot of an S4 object
rho | Function returning the adjusting parameter rho slot of an S4 object
rpbrPar | Representing Randomized Permuted Block Randomization
rtbdPar | Representing Randomized Truncated Binomial Design

## -- S --

saveAssess | Saving an assess object
saveRand | Saving a randomization lists
seed | Function returning the allocation seed slot of an object
selBias | Representing selection bias
setPower | Representing the power
sigma | Function returning the standard deviation slot of a normEndp S4 object
summary | Summary of assessments of a randomization procedure
summary-method | Summary of assessments of a randomization procedure

## -- T --

tbdPar | Representing Truncated Binomal Design
TV | Function returning the sample size slot of an S4 object
type | Get type of an object

## -- U --

udPar | Representing Wei's Urn Design

## -- misc --

$-method | Method defining the $ operator for the assessemnt class
$-method | Method defining the $ operator for the assessemnt class
$-method | Method defining the $ operator for the derFunc class
$-method | Method defining the $ operator for the desFunc class
$-method | Method defining the $ operator for the assessemnt class
$-method | Method defining the $ operator for the endpoint class
$-method | Method defining the $ operator for the evaluation class
$-method | Method defining the $ operator for the issue class
$-method | Method defining the $ operator for the probUnDesirable class
$-method | Method defining the $ operator for the randPar class
$-method | Method defining the $ operator for the randSeq class